منابع مشابه
Fading sodium channels in failing hearts.
Heart failure (HF) affects over 5 million Americans with 550 000 new cases diagnosed each year. Despite advances in understanding and treatment the mortality rate remains extremely high with up to 50% of the patients dying suddenly.1 Ventricular arrhythmias are frequently the cause of sudden death in these heart failure patients. The mechanisms for these arrhythmias remain the focus of fervent ...
متن کاملOxidative capacity in failing hearts.
Although high-energy phosphate metabolism is abnormal in failing hearts [congestive heart failure (CHF)], it is unclear whether oxidative capacity is impaired. This study used the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP) to determine whether reserve oxidative capacity exists during the high workload produced by catecholamine infusion in hypertrophied and failing hearts. Left ventr...
متن کاملFailing Human Hearts
Background A variety of previous studies have demonstrated reduced diastolic potential and electrical activity in atrial specimens from patients with heart disease. Although K' channels play a major role in determining resting membrane potential and repolarization of the action potential, little is known about the effects of preexisting heart disease on human atrial K' channel activity. Methods...
متن کاملFailing ageing hearts.
Chronic heart failure is a major and increasing cause of morbidity and mortality. Although it is widely recognized that chronic heart failure affects the elderly, little attention has been given to its study specifically in this patient group. For example, patients with chronic heart failure in clinical trials frequently have an average age of around 60 years, in comparison to one of nearer 80 ...
متن کاملCalcium Current Channels Induced by Catecholamines in Chick Embryonic Hearts Whose Fast Sodium Channels
In isolated ventricles of old (9-19 day) chick embryonic hearts made inexcitable by inactivating the fast sodium channels with either tetrodotoxin (TTX) or elevated external potassium, catecholamines induced slow electrical responses and concomitant contractions within 1-3 minutes. These slow responses had a higher threshold and propagated at a slower velocity than did the normal action potenti...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.165597